NOTICIAS CIENCIAS FISIOLÓGICAS

Frontiers in Physiology

• Circadian rhythm, glucose metabolism and diabetic complications: the role of glucokinase and the enlightenment on future treatment
  The circadian clock, an innate timing mechanism, governs a variety of physiological activities by producing near-24-h cycles in gene expression. These cycles are reflected in patterns of metabolism and behavior. This system consists of two parts: one is the central clock located in the suprachiasmatic nucleus of the hypothalamus, and the other is the peripheral […]
• Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements
  Measurement of the ventricular action potential (AP) via whole-cell patch clamp is an important contributor to cardiac electrophysiological research. Neonatal rat ventricular cardiomyocytes (NRVCM) are a commonly used model, in particular for stressor- or drug-related questions. High variability of APs and individual methodological settings hinder comparison both in individual studies and, to an even greater […]
• Sex-dependent alterations of colonic epithelial permeability: relevance to irritable bowel syndrome
  IntroductionIncreased intestinal permeability is a possible pathophysiological mechanism of irritable bowel syndrome (IBS). Increased colonic epithelial permeability is associated with visceral nociception in rodents and abdominal pain severity in IBS patients. Although IBS is more common in women, most studies on IBS-associated epithelial dysfunction have largely overlooked sex as a biologic variable.MethodsMen and women with […]
• Inverse association between atherogenic index of plasma and testosterone in US adult males: A large cross-sectional study from the NAHNES 2011–2016
  Background and objectivesThe atherogenic index of plasma (AIP), defined as log10 (triglycerides/high-density lipoprotein cholesterol), serves as a biomarker for atherosclerosis and cardiovascular disease (CVD). It is also associated with conditions such as type 2 diabetes, insulin resistance, depression, and both cardiovascular and overall mortality. Serum lipids have been proven to influence serum testosterone levels, and […]
• Duration-dependent physiological, perceptual, and technical changes during a 2-hour low-intensity training session in female cross-country skiers
  PurposeThis study investigated duration-dependent physiological, perceptual, and technical changes during a 2-hour low-intensity training (LIT) session in female cross-country (XC) skiers.MethodsTwelve national-level female XC skiers (age:21.4 ± 2.7 years, maximal oxygen uptake: 58.1 ± 5.3 mL min⁻1·kg⁻1) performed a 2-hour LIT session, roller-ski skating in the laboratory while alternating between two main sub-techniques (Gear-2 and Gear-3). Acute physiological […]
• “Distribution of dominant wavelengths predicts jackdaw (Corvus monedula) color discrimination performance”
  Color vision is an important perceptual ability in most species and a crucial capacity underlying any cognitive task working with color stimuli. Birds are known for their outstanding vision and tetrachromacy. Two jackdaws were trained to indicate whether they perceive two colors as same or different. The dominant wavelengths of the experimental colors were assessed […]
• Molecular characterization of the heterogeneity of satellite cell populations isolated from an individual Turkey pectoralis major muscle
  Satellite cells (SCs) are myogenic stem cells responsible for post hatch muscle growth and the regeneration of muscle fibers. Satellite cells are not a homogenous population of cells within a muscle and have variable rates of proliferation and differentiation even within a single fiber type muscle like the turkey pectoralis major muscle. In this study, […]
• Comparisons of urinary bladder responses to common antimuscarinics reveals unique effects of darifenacin
  IntroductionAntimuscarinics are the first-line pharmaceutical treatment for overactive bladder (OAB). However, some literature suggests that responses to these antimuscarinics can influence a variety of non-muscarinic receptors. This study aimed to identify any non-muscarinic influences on contraction from commonly prescribed clinical antimuscarinics using porcine detrusor or urothelium with lamina propria (U&LP) tissues.MethodsPorcine bladders were dissected into […]
• Simultaneous assessment of mitochondrial and vascular function using the Flow Mediated Skin Fluorescence technique
  Flow Mediated Skin Fluorescence (FMSF) is a new non-invasive diagnostic method for assessing vascular circulation and/or metabolic regulation. The method measures stimulation of the circulation in response to post-occlusive reactive hyperemia (PORH). It analyzes the dynamical changes in NADH fluorescence emitted from skin tissue, providing information on mitochondrial metabolic status and intracellular oxygen delivery through […]
• Differences between macrovascular and microvascular functions in pregnant women with chronic hypertension or preeclampsia: new insights into maternal vascular health
  IntroductionHypertensive disorders of pregnancy, including chronic hypertension (CH) and preeclampsia (PE), stand as prominent global contributors to maternal and perinatal morbidity and mortality. Endothelial dysfunction plays a central role in the pathophysiology of these conditions. This dysfunction impacts blood flow and the regulation of vascular response, potentially leading to alterations in the remodeling of blood […]